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The Risks of Mixed Metals in Your Mouth: Immune and Systemic Concerns

When several different metals are present in the mouth, such as dental amalgams (which contain mercury, silver, tin, copper), crowns or implants made of titanium, nickel, aluminum, and other metals, there is potential for complex interactions that can affect your health. The U.S. Food and Drug Administration (FDA) has, in recent years, reviewed the scientific evidence related to these exposures, especially concerning immune dysregulation and systemic effects. 

Here are some of the key concerns:

Immune & Inflammatory Responses

• Some people may have heightened immune or allergic reactions to specific metals or metal alloys. Over time, corrosion or wear of metal restorations can release metal ions into surrounding tissues, where they may trigger chronic inflammation. 
• The FDA’s “Biological Responses to Metal Implants” review specifically acknowledges that certain individuals show a local or systemic immune/inflammatory reaction to implanted metal devices. The degree and severity of the reaction can depend on the type of metal, the amount released, and individual sensitivity. 

Systemic Effects & Vulnerable Groups

• • Metal exposure (notably mercury from dental amalgam) can have neurological, renal (kidney), and developmental effects at higher exposure levels. While the FDA’s stance remains that typical mercury exposure from properly placed and maintained amalgam is unlikely to cause harm for most people, certain high-risk populations may be more susceptible. 

• High-risk groups include pregnant women (including fetuses), young children, people with kidney disease, those with pre-existing neurological conditions, and individuals with known metal allergies or hypersensitivities.

• Other nations, such as those in the European Union, have taken a sweeping stance against the continued use of mercury amalgam fillings in their countries. Hopefully the United States will follow suit in the not-too-distant future.

Interactions Among Mixed Metals

• When different metals are used in proximity (for example, an amalgam filling next to a metal crown), galvanic currents (tiny electrical potentials) and corrosion can increase release of metal ions. These ions can travel systemically and may accumulate in organs. Over time, accumulation plus chronic immune stimulation may contribute to oxidative stress, immune dysfunction, and other inflammatory disorders.
• The FDA has flagged that there remain uncertainties: the long-term accumulation of metal ions, and how combinations of different metals might have additive or synergistic negative effects, especially in sensitive individuals. 

What This Means for You

At Blodgett Dental Care, we believe in informed consent and personalized care. If you have multiple metal restorations, or if another dentist has recommended new metal-based dental work, here are steps to consider:

1. Evaluate metal types and locations: Different metals corrode differently. Mixed metals in close contact are more likely to cause release of ions.
2. Choose ceramic and composite options: Non-metallic restorations (ceramics, composite resin, zirconia) reduce health risks and are less likely to stimulate any immune response.
3. Obtain a BioComp report: BioComp is a dental material sensitivity test that defines which current dental materials are compatible with your body. Before investing significant time, energy, and money in your oral health, obtain a BioComp report so that you know for sure which materials will work best with your body.
4. Monitor health: Be alert for signs of sensitivity—rashes, unexplained inflammation, neurological symptoms—and consult with a dentist knowledgeable in Biological Dentistry and your physician or other functional healthcare provider.
5. Maintain optimal nutrition and oral health: Your daily choices of what you eat, drink, and how often you engage in food and beverage consumption will directly influence your gastrointestinal health, nutrient absorption, and the quality of your dental restorations. Working with a Biological Dentist who is Board Certified in Naturopathic Medical Dentistry and Integrative Biological Dental Medicine will empower you to be supported at the highest level in your health journey.